GLOSSARY OF TERMS USED IN TIME SERIES ANALYSIS
OF CARDIOVASCULAR DATA
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ECG-DERIVED RESPIRATION
Respiratory signal derived from the ECG by assessing the fluctuations in the cardiac electric axis due to respiration.

Motion of the electrods with respect to the heart -- due to expansions and contractions of the chest -- and changes in thoracic impedance -- due to filling and empting of the lungs --  influence chest surface ECG. Morphology changes in the ECG waves allow to derive a signal proportional to the respiratory movement on a beat-by-beat basis. Typically, a respiratory signal is derived by computing the ratio of the areas of QRS complexes in two different leads. This tecnique was validated with data derived from sleep apnoea studies and Cheynes-Stockes patients, and applied to study breathing at high altitude and during chronic congestive heart failure. A different approach is based on the assessment of direction changes of successive vectorcardiogram (VCG) loops.

References
Moody GB et al (1985) Derivation of Respiratory Signals from Multi-lead ECGs.Computers in Cardiology.
Moody GB et al (1986) Clinical Validation of the ECG-Derived Respiration (EDR) Technique.Computers in Cardiology
Lipsitz LA et al (1995) Heart rate and respiratory rhythm dynamics on ascent to high altitude.Br Heart J
Saul JP et al (1988) Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis.Am J Cardiol
Leanderson S et al (2003) Estimation of the respiratory frequency using spatial information in the VCG Med Eng Phys.


(PC 10-03-2003)

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