GLOSSARY OF TERMS USED IN TIME SERIES ANALYSIS
OF CARDIOVASCULAR DATA
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COSINOR ANALYSIS

Least square approximation of time series using a cosine function of known period.

The following function is approximated to experimental data:

where Mesor (acronym for midline estimating statistic of rhythm) is the mean of the oscillation, A the amplitude, P the prefixed period and Acrophase the timing of the cosine maximum. In the analysis of circadian rhythms, P=24 hours.
 

References:
Smolensky MH, Tatar SE, Bergman SA, Losman JG, Barnard CN, Dacso CC, Kraft IA (1976) Circadian rhythmic aspects of human cardiovascular function: a review by chronobiologic statistical methods Chronobiologia 3, 337-370
Massin MM et al. (2000)  Circadian rhythm of heart rate and heart rate variability. Arch Dis Child.
Tabata M et al  (2000)  Cosinor analysis of heart rate variability in ambulatory migraineurs. Headache.
Lentz MJ (1990) Time-series analysis--cosinor analysis: a special case.West J Nurs Res


(PC 07-09-1999)

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